Details

Autor(en) / Beteiligte

• Laihinen, Arto O
• Rinne, Juha O
• Ruottinen, Hanna M
• Naagren, Kjell a
• Lehikoinen, Pertti K
• Oikonen, Vesa J
• Ruotsalainen, Ulla H
• Rinne, Urpo K

Titel

PET Studies on Dopamine D1 Receptors in the Human Brain with Carbon-11-SCH 39166 and Carbon-11-NNC 756

Ist Teil von

• The Journal of nuclear medicine (1978), 1994-12, Vol.35 (12), p.1916-1920

Ort / Verlag

United States: Soc Nuclear Med

Erscheinungsjahr

1994

Quelle

MEDLINE

Beschreibungen/Notizen

• PET studies were carried out on brain dopamine D1 receptors using two new ligands, [11C]SCH 39166 and [11C]NNC 756. Four normal subjects and eight predominantly unilateral patients with early Parkinson's disease were investigated. Each of them underwent both a PET scan with [11C]SCH 39166 and one with [11C]NNC 756. A dose of about 185 MBq (5 mCi) of these ligands was administered intravenously and a dynamic PET scan with an ECAT 931/08 PET camera was carried out. Ratios between the striatal and cerebellar uptake of these compounds were calculated. Both [11C]SCH 39166 and [11C]NNC 756 accumulated in the striatum. There was also some neocortical binding; 75% of the striatal value in the case of [11C]SCH 39166 and 60% with [11C]NNC 756 which displayed higher (p < 0.01) uptake in the striatum than [11C]SCH 39166. There were no significant side-to-side differences in the controls nor in the parkinsonian patients. These results imply that both [11C]SCH 39166 and [11C]NNC 756 can be used in PET studies for the visualization and quantification of dopamine D1 receptors. Since [11C]NNC 756 has a significantly better signal-to-noise ratio in the striatum than [11C]SCH 39166, it seems to offer definite advantages for studies of D1 receptors.