Details

Autor(en) / Beteiligte

• Burton, Dennis R.
• Pyati, Jayashree
• Koduri, Raju
• Sharp, Stephen J.
• Thornton, George B.
• Paul W. H. I. Parren
• Lynette S. W. Sawyer
• Hendry, R. Michael
• Dunlop, Nancy
• Nara, Peter L.
• Lamacchia, Michael
• Garratty, Eileen
• Stiehm, E. Richard
• Bryson, Yvonne J.
• Cao, Yunzhen
• Moore, John P.
• Ho, David D.
• Barbas, Carlos F.

Titel

Efficient Neutralization of Primary Isolates of HIV-1 by a Recombinant Human Monoclonal Antibody

Ist Teil von

• Science (American Association for the Advancement of Science), 1994-11, Vol.266 (5187), p.1024-1027

Ort / Verlag

Washington, DC: American Society for the Advancement of Science

Erscheinungsjahr

1994

Quelle

MEDLINE

Beschreibungen/Notizen

• The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines. A recombinant human antibody to envelope glycoprotein gp120 was generated and used to show that primary isolates are not refractory to antibody neutralization. The recombinant antibody neutralized more than 75 percent of the primary isolates tested at concentrations that could be achieved by passive immunization, for example, to interrupt maternal-fetal transmission of virus. The broad specificity and efficacy of the antibody implies the conservation of a structural feature on gp120, which could be important in vaccine design.