Details

Autor(en) / Beteiligte

• Montgomery, Grant W.
• Lord, Eric A.
• Penty, Joanne M.
• Dodds, Ken G.
• Broad, Tom E.
• Cambridge, Lisa
• Sunden, Sara L.F.
• Stone, Roger T.
• Crawford, Allan M.

Titel

The Booroola Fecundity (FecB) Gene Maps to Sheep Chromosome 6

Ist Teil von

• Genomics (San Diego, Calif.), 1994-07, Vol.22 (1), p.148-153

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

1994

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The Booroola (FecB) mutation in sheep is linked to markers from a region of syntenic homology to human chromosome HSA4q, but the chromosomal location in sheep has not been determined. Analysis of linkage in Booroola half-sib pedigrees and 17 full-sib families identified genetic linkage between platelet-derived growth factor receptor-α (PDGFRA) and αs1-casein (CSN1S1) at 12 cM (Zmax = 9.14) and between PDGFRA and the microsatellite markers BM143 and OarHH55 (Zmax = 6.28 and 3.83, respectively). The microsatellite markers OarAE101 and BM143 and genes from the linkage group (PDGFRA, SPP1, and EGF) were mapped in a partial sheep × hamster somatic cell hybrid panel. All markers identified bands specific to somatic cell hybrids containing the sheep chromosome t1 (rob6;24) or t1q (chromosome 6). In sheep the casein genes αs1 (CSN1S1), αs2 (CSN1S2), β (CSN2), and κ (CSN3) are tightly linked, and CSN2 has been mapped to sheep chromosome 6q23-q31. We conclude that the Booroola mutation is located within a conserved syntenic group that maps to sheep chromosome 6.