Details

Autor(en) / Beteiligte

• ALTSZULER, N
• PUMA, F
• WINKLER, B
• FONTAN, N
• SAUDEK, C. D

Titel

Oxytocin increases extrapancreatic glucagon secretion and glucose production in pancreatectomized dogs

Ist Teil von

• Experimental biology and medicine (Maywood, N.J.), 1986-05, Vol.182 (1), p.79-83

Ort / Verlag

Malden, MA: Blackwell Science

Erscheinungsjahr

1986

Quelle

MEDLINE

Beschreibungen/Notizen

• Infusion of oxytocin into normal dogs increases plasma levels of insulin and glucagon and glucose production and uptake. To determine whether infused oxytocin also increases glucagon secretion from extrapancreatic sites, pancreatectomized dogs, off insulin for 18 hr, were infused with oxytocin and plasma glucagon, and glucose production and uptake were measured using the [6-3H]glucose primer-infusion technique. The diabetic dogs, in the control period, had elevated plasma glucose and glucagon levels, an increased rate of glucose production, and a relative decrease in glucose uptake (decreased clearance). Infusion of oxytocin (500 microU/kg/min) caused a rise in plasma glucagon and glucose levels, increased glucose production, and further decreased glucose clearance. It is concluded that oxytocin can stimulate secretion of extrapancreatic glucagon, which contributes to the increased glucose production.