Medical hypotheses, 1994-06, Vol.42 (6), p.397-399
1994
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- Autor(en) / Beteiligte
- Titel
- A novel hypothesis: Specific oncogenes and tumor suppression genes are involved in the expression of the proopiomelanocortin gene by small cell lung cancer
- Ist Teil von
- Medical hypotheses, 1994-06, Vol.42 (6), p.397-399
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 1994
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The endogenous opioid β-endorphin, a derivative of proopiomelanocortin, stimulates the growth of cloned human small cell lung carcinoma. The present hypothesis states that mutations of the retinoblastoma gene (a tumor suppressor gene) associated to the malignant transformation of bronchial cells would trigger a cascade of biomolecular events leading to ‘de novo’ proopiomelanocortin expression in small cell lung carcinoma.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-9877eISSN: 1532-2777DOI: 10.1016/0306-9877(94)90162-7Titel-ID: cdi_proquest_miscellaneous_76761705
- Format
- –
- Schlagworte
- ACTH Syndrome, Ectopic - etiology, beta-Endorphin - metabolism, Biological and medical sciences, Carcinoma, Small Cell - genetics, Carcinoma, Small Cell - metabolism, Cushing Syndrome - etiology, Cushing Syndrome - genetics, Female, Gene Expression Regulation, Neoplastic, Genes, fos, Genes, Retinoblastoma, Hormones, Ectopic - biosynthesis, Hormones, Ectopic - genetics, Humans, Lung Neoplasms - genetics, Lung Neoplasms - metabolism, Medical sciences, Models, Biological, Neoplasm Proteins - biosynthesis, Neoplasm Proteins - genetics, Pneumology, Pro-Opiomelanocortin - biosynthesis, Pro-Opiomelanocortin - genetics, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-fos - physiology, Retinoblastoma Protein - deficiency, Retinoblastoma Protein - physiology, Tumors of the respiratory system and mediastinum