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Western blot assay for prostate-specific membrane antigen in serum of prostate cancer patients
The Prostate, 1994-10, Vol.25 (4), p.219-223
Rochon, Yvan P.
Horoszewicz, Julius S.
Boynton, Alton L.
Holmes, Eric H.
Barren III, Robert J.
Erickson, Sheila J.
Kenny, Gerald M.
Murphy, Gerald P.
1994
Details
Autor(en) / Beteiligte
Rochon, Yvan P.
Horoszewicz, Julius S.
Boynton, Alton L.
Holmes, Eric H.
Barren III, Robert J.
Erickson, Sheila J.
Kenny, Gerald M.
Murphy, Gerald P.
Titel
Western blot assay for prostate-specific membrane antigen in serum of prostate cancer patients
Ist Teil von
The Prostate, 1994-10, Vol.25 (4), p.219-223
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1994
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
There is a need for the development of new diagnostic tools for the early detection of prostate cancer. A candidate molecule for a new screening test is a prostate‐specific membrane antigen (PSM) recognized by the monoclonal antibody 7E11.C5. We carried out studies aimed at identifying PSM in the serum of normal and benign prostatic hyperplasia (BPH) donors and patients with adenocarcinoma of the prostate, in order to judge whether the development of a serum assay using this marker was feasible. By Western blotting, we found significant levels of PSM in serum samples from prostatic cancer patients, in the seminal fluid of pooled normal donors, in BPH patients, and in normal male sera. Similar to prostate‐specific antigen (PSA), PSM was present in seminal plasma in higher concentrations than in serum, and PSM levels in prostatic cancer patients were significantly higher than in normal controls. These data suggest that the development of an assay utilizing the PSM and new monoclonal antibodies directed against the antigen, could provide a feasible test for prostatic cancers. © 1994 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0270-4137
eISSN: 1097-0045
DOI: 10.1002/pros.2990250408
Titel-ID: cdi_proquest_miscellaneous_76710881
Format
–
Schlagworte
Adenocarcinoma - blood
,
Adenocarcinoma - diagnosis
,
Adenocarcinoma - immunology
,
Antigens, Neoplasm - analysis
,
Antigens, Neoplasm - blood
,
Antigens, Surface - analysis
,
Antigens, Surface - blood
,
Binding, Competitive
,
Biological and medical sciences
,
Blotting, Western
,
Cell Line
,
Enzyme-Linked Immunosorbent Assay
,
Glutamate Carboxypeptidase II
,
Humans
,
Male
,
Medical sciences
,
monoclonal antibodies
,
Nephrology. Urinary tract diseases
,
prostatic adenocarcinoma
,
Prostatic Neoplasms - blood
,
Prostatic Neoplasms - diagnosis
,
Prostatic Neoplasms - immunology
,
PSM
,
Semen - chemistry
,
serodiagnosis
,
Tumors of the urinary system
,
Urinary tract. Prostate gland
,
Western blotting
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