Details

Autor(en) / Beteiligte

• SAKANE, TOSHIYASU
• AKIZUKI, MOTOHIRO
• YAMASHITA, SHINJI
• SEZAKI, HITOSHI
• NADAI, TANEKAZU

Titel

Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug

Ist Teil von

• Journal of pharmacy and pharmacology, 1994-05, Vol.46 (5), p.378-379

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1994

Quelle

MEDLINE

Beschreibungen/Notizen

• — We aimed to clarify the relationship between drug dissociation (sulphisomidine) and its direct transport from the nasal cavity to the cerebrospinal fluid (CSF). Rat nasal cavities were perfused in a single pass system with buffers (pH 5·5, 6·5, 7·4, 8·7 and 9·4). Plasma and CSF were collected and the concentration of sulphisomidine was measured. Nasal clearance increased with the increase in the un‐ionized fraction of the drug. The ratio of the drug concentration in CSF to that in the nasal perfusion fluid (the index of the degree of the drug transport from the nasal cavity to CSF), was changed in accordance with the un‐ionized fraction of drug. These results show that both the nasal absorption and the drug transport conform to the pH partition theory.