Details

Autor(en) / Beteiligte

• LEESON, l. j
• ADAIR, D
• CLEVENGER, J
• CHIANG, N

Titel

The in vitro development of extended-release solid oral dosage forms

Ist Teil von

• Journal of pharmacokinetics and biopharmaceutics, 1985-10, Vol.13 (5), p.493-514

Ort / Verlag

New York, NY: Plenum

Erscheinungsjahr

1985

Quelle

MEDLINE

Beschreibungen/Notizen

• A system is described for developing extended-release products, based upon predicting or simulating the entire plasma level-time curve to be expected from the administration of a controlled-release oral dosage form. Termed "biorelevant dissolution," it employs the product's in vitro dissolution behavior and the drug's pharmacokinetic parameters in conjunction with a classical pharmacokinetic model. The basic system is described along with some pertinent examples.