Details

Autor(en) / Beteiligte

• Matsuda, Ayako
• Kamata, Ikuko
• Iwamoto, Yasuhiko
• Sakamoto, Yoshikazu
• Kuzuya, Takeshi

Titel

A comparison of serum C-peptide response to intravenous glucagon, and urine C-peptide, as indexes of insulin dependence

Ist Teil von

• Diabetes research and clinical practice, 1985-10, Vol.1 (3), p.161-167

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

1985

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Serum C-peptide (SCPR) at fasting and after intravenous injection of glucagon was evaluated in diabetic patients with various degrees of insulin dependence, and compared with 24 h urine C-peptide (UCPR). Fasting SCPR did not differ between healthy subjects and sulfonylurea-treated patients (SU) who were considered to have definite non-insulin-dependent diabetes (NIDDM); but was significantly lower in patients with insulin-dependent diabetes (IDDM) (0.24 ± 0.10 ng/ml in IDDM vs. 1.43 ± 0.61 ng/ml in SU, P < 0.001). SCPR reached a peak at 6 min after glucagon injection, except for the IDDM group. The SCPR response at 6 min after 1 mg glucagon injection was significantly lower in the SU (NIDDM) group than in the normal group (2.86 ± 1.21 vs. 4.69 ± 1.47 ng/ml, P < 0.001). In the IDDM group, there was no increase of SCPR after glucagon injection. Among diabetic patients, SCPR response to glucagon correlated positively to the amounts of UCPR ( P < 0.001). By analysis of the distribution patterns of SCPR response to intravenous glucagon, SCPR of 1.0 ng/ml and the increment of SCPR of 0.5 ng/ml at 6 min are to be used as cut-off points to differentiate IDDM and NIDDM. These values correspond roughly to the UCPR values below 20 μg/day and above 30 μg/day, which we previously proposed as indexes to differentiate insulin-dependent and non-insulin-dependent diabetes.