Details

Autor(en) / Beteiligte

• SUN, HAO H.
• BYARD, STEPHEN J.
• COOPER, RAYMOND

Titel

REVISED NMR ASSIGNMENTS FOR THE CHOLECYSTOKININ ANTAGONIST ASPERLICIN

Ist Teil von

• The Journal of Antibiotics, 1994/05/25, Vol.47(5), pp.599-601

Ort / Verlag

Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

Erscheinungsjahr

1994

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Asperlicin (1), a competitive cholecystokinin (CCK) antagonist, produced from Aspergillus alliaceus, was originally characterized primarily by means of X-ray crystallography. The compound contains a 1,4-benzodiazepine ring with a quinazolone fused to the 1,2-positions, and a 3-substituted moiety condensed from tryptophan and leucine. This was the first reported naturally occurring nonpeptide antagonist of a peptide receptor. We have carried out a detailed NMR analysis leading to unambiguous assignments of both super(1)H and super(13)C data for asperlicin, reported herein. The super(1)H NMR spectrum of 1 in CDCl sub(3)-CD sub(3)OD (4:1) showed the presence of 2 methyls, 2 methylenes, 4 methines and 12 well-resolved aromatic protons.