Details

Autor(en) / Beteiligte

• Walker, Keith A. M
• Sjogren, Eric B
• Matthews, Thomas R

Titel

Antitrichomonal activity of mesoionic thiazolo[3,2-a]pyridines

Ist Teil von

• Journal of medicinal chemistry, 1985-11, Vol.28 (11), p.1673-1679

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

1985

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Screening of mesoionic compounds as potential electron acceptors by analogy with metronidazole led to the finding of in vitro antitrichomonal activity for anhydro-2-phenyl-3-hydroxythiazolo [3,2-a]pyridinium hydroxide (1). In a series of analogues, potent in vitro activity was found to be associated with amino substitution; however, such activity was dependent on specific structural features and not on the reduction potential. The most active compounds showed only poor in vivo activity.