Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons
Ist Teil von
The Journal of biological chemistry, 1994-05, Vol.269 (19), p.14088-14093
Ort / Verlag
Bethesda, MD: American Society for Biochemistry and Molecular Biology
Erscheinungsjahr
1994
Quelle
MEDLINE
Beschreibungen/Notizen
The type I interferons (IFNs) are a family of multifunctional cytokines which includes the 15 IFN alpha subtypes and IFN beta.
These IFNs compete for binding to cell surface receptors. However, murine cells transfected with a cDNA for a human IFN alpha
receptor (IFNAR) developed an antiviral response only to human IFN alpha B, but not to human IFN alpha 2 nor -beta(1). In
this study we show, using a panel of CHO-human chromosome 21 hybrid cell lines which all express IFNAR, that only those containing
the region 21q22.2 to 21q22.3 transduce signals for IFN responses. Two such hybrid cell lines responded to IFNs alpha 2, -alpha
B and -beta by induction of 2'-5' oligoadenylate synthetase and resistance to viral infection. Other hybrid cell lines, that
lacked the region 21q22.2-3, failed to transduce signals as above; even though they expressed IFNAR and bound human IFN alpha
2, -alpha B, and -beta. These data demonstrate that a gene(s) located in the region 21q22.2-3 encodes a factor(s) which is
necessary for signaling but does not influence ligand binding. This factor is not the cofactor required for IFN gamma signaling
which is located in the region 21p to 21q22.1(2).