Details

Autor(en) / Beteiligte

• COOMBES, J. D
• NORRIS, D. B
• RISING, T. J
• ROSS, B. C
• STEWARD, A

Titel

In vitro histamine H2-antagonist activity of the novel compound HUK 978

Ist Teil von

• Life sciences (1973), 1985-11, Vol.37 (18), p.1711-1718

Ort / Verlag

Amsterdam: Elsevier

Erscheinungsjahr

1985

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Histamine stimulated adenylate cyclase from guinea-pig fundic mucosa and 3H-tiotidine binding in guinea-pig cerebral cortex were used to assess the in-vitro histamine H2-activity of the novel H2-antagonist HUK 978. The results showed that HUK 978 was a more potent H2-antagonist than either cimetidine or ranitidine. HUK 978 was also shown to be devoid of activity at the histamine H1-receptor, the muscarinic receptor and the alpha and beta-adrenergic receptors.