FEBS letters, 1985-11, Vol.192 (1), p.33-36
1985
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Details
- Autor(en) / Beteiligte
- Titel
- Myeloperoxidase oxidation of sulfur-centered and benzoic acid hydroxyl radical scavengers
- Ist Teil von
- FEBS letters, 1985-11, Vol.192 (1), p.33-36
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1985
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Myeloperoxidase (MPO) oxidizes sulfur-centered and benzoate hydroxyl radical scavengers through formation of HOCl. Sulfur-centered hydroxyl radical scavengers compete with benzoate as antioxidants ofHOCl. We conclude from these observations that competition experiments between benzoate and sulfur-centered hydroxyl radical scavengers are not sufficiently specific to infer participation of hydroxyl radicals in oxidative reactions mediated by neutrophils because of the unique action of MPO in affecting oxidation of the test radical scavengers.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/0014-5793(85)80037-5Titel-ID: cdi_proquest_miscellaneous_76430283
- Format
- –
- Schlagworte
- Analytical, structural and metabolic biochemistry, Benzoate decarboxylation, Benzoates - blood, Benzoic Acid, Binding, Competitive, Biological and medical sciences, Dimethyl Sulfoxide - metabolism, Enzymes and enzyme inhibitors, Fundamental and applied biological sciences. Psychology, Humans, Hydroxides - blood, Hydroxyl Radical, Hypochlorous acid, Hypochlorous Acid - blood, Kinetics, Mannitol - metabolism, Methionine - analogs & derivatives, Methionine - metabolism, Myeloperoxidase, Neutrophil, Neutrophils - metabolism, Oxidation-Reduction, Oxidoreductases, Peroxidase - blood, Sulfur - blood, Superoxide Dismutase - metabolism, Taurine - analogs & derivatives, Taurine - metabolism