Details

Autor(en) / Beteiligte

• Corell, Robert A.
• Riordan, Jessica A.
• Gross, Robert H.

Titel

Chemical Induction of Stress Proteins Does Not Induce Splicing Thermotolerance under Conditions Producing Survival Thermotolerance

Ist Teil von

• Experimental cell research, 1994-04, Vol.211 (2), p.189-196

Ort / Verlag

Orlando, FL: Elsevier Inc

Erscheinungsjahr

1994

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Cell survival during a severe heat stress can be enhanced when heat shock proteins are induced prior to the severe heat treatment. Induction can be accomplished either by heat or chemical treatments. The increase in survival at these severe elevated temperatures after pretreatment has been referred to as thermotolerance, which we now refer to as survival thermotolerance. It has also been shown previously that mild heat treatment allows splicing in cells subjected to a severe heat treatment, now referred to as splicing thermotolerance. The experiments shown here demonstrate that even though chemical induction of the heat shock proteins leads to survival thermotolerance, this same treatment does not induce splicing thermotolerance. These are the first results that demonstrate at least two distinct aspects of thermotolerance.