FEBS letters, 1994-04, Vol.342 (2), p.203-208
1994
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain
- Ist Teil von
- FEBS letters, 1994-04, Vol.342 (2), p.203-208
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1994
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tau protein kinase II (TPKII) was reported previously to be composed of a neuron-rich cdc2-related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2-related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/0014-5793(94)80501-6Titel-ID: cdi_proquest_miscellaneous_76413216
- Format
- –
- Schlagworte
- Alzheimer's disease, Amino Acid Sequence, Analytical, structural and metabolic biochemistry, Animals, Base Sequence, Biological and medical sciences, Brain - metabolism, Cattle, Cyclin-Dependent Kinase 5, Cyclin-Dependent Kinases, Cyclins - genetics, DNA Primers - genetics, DNA Probes - genetics, DNA, Complementary - genetics, Enzyme Activation, Enzymes and enzyme inhibitors, Fundamental and applied biological sciences. Psychology, Humans, In Vitro Techniques, Molecular Sequence Data, Molecular Weight, Paired helical filament, Peptide Fragments - chemistry, Peptide Fragments - genetics, Protein Conformation, Protein Kinases - metabolism, Protein-Serine-Threonine Kinases - chemistry, Protein-Serine-Threonine Kinases - genetics, Protein-Serine-Threonine Kinases - metabolism, Sequence Homology, Amino Acid, Tag sequence, Tau protein, Transferases