Details

Autor(en) / Beteiligte

• NICHOLSON, R. I
• MCCLELLAND, R. A
• GEE, J. M. W
• MANNING, D. L
• CANNON, P
• ROBERTSON, J. F. R
• ELLIS, I. O
• BLAMEY, R. W

Titel

Transforming growth factor-α and endocrine sensitivity in breast cancer

Ist Teil von

• Cancer research (Chicago, Ill.), 1994-04, Vol.54 (7), p.1684-1689

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

1994

Quelle

MEDLINE

Beschreibungen/Notizen

• The expression of transforming growth factor-alpha (TGF-alpha) has been evaluated in 51 breast cancers of known responsiveness to endocrine therapy using immunohistochemistry. High levels of TGF-alpha were observed in 65% of tumors and showed no relationship with tumor estrogen receptor or epidermal growth factor receptor status or Ki67 immunostaining. TGF-alpha levels did, however, relate to the endocrine sensitivity of the disease, with unresponsive tumors frequently showing high levels of TGF-alpha immunoreactivity. This relationship was observed in estrogen receptor-positive disease and was independent of the epidermal growth factor receptor status of the tumor. No quantitative association between TGF-alpha and Ki67 immunostaining was observed in any of the subcategories of tumors. These data infer a role for TGF-alpha in the development of endocrine insensitivity in estrogen receptor-positive breast cancer by mechanisms which appear independent of tumor growth fraction, as determined by Ki67 immunostaining.