Details

Autor(en) / Beteiligte

• Liskowsky, David R.
• Potter, Lincoln T.

Titel

Muscarine-binding sites localized to cortical dopamine terminals

Ist Teil von

• Neuroscience letters, 1985-07, Vol.58 (2), p.229-233

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

1985

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The effects of lesions to the mesocortical dopaminergic system on D 2 dopamine receptors and muscarine receptors in the frontal cortex of the rat was examined. Four weeks following 6-hydroxydopamine lesioning of the ventral tegmental area, there was a 26% increase in the number of [ 3]Hspiroperidol sites, and a 13% decrease in the number of [ 3H]oxotremorine-M sites in the frontal cortex, indicating a development of D 2 receptor supersensitivity, as a result of deafferentation, and a loss of acetylcholine sites, as a result of terminal degeneration. This demonstrates that in the frontal cortex, as in the striatum and nucleus accumbens, the activity of dopaminergic terminals may be partially modulated by cholinergic inputs.