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Effects of salbutamol upon performance on an operant screen for antidepressants
Ist Teil von
Psychopharmacologia, 1993-11, Vol.113 (1), p.1-10
Ort / Verlag
Berlin: Springer
Erscheinungsjahr
1993
Link zum Volltext
Quelle
SpringerLink (Online service)
Beschreibungen/Notizen
The beta adrenergic (beta) agonist salbutamol increased reinforcement rates and decreased response rates on a differential-reinforcement-of-low-rate (DRL) 72-S schedule. These changes in DRL 72-S schedule performance are also produced by most clinically used antidepressants. The effects of salbutamol on a DRL 72-S schedule were dose-dependently antagonized by the beta antagonist metoprolol, but not changed by the 5HT antagonist methysergide. Additionally, neither salbutamol nor the antagonism of salbutamol by metoprolol caused disruption of DRL 72-S schedule performance. These results indicate that stimulation of beta receptors, and not of 5HT receptors, mediates salbutamol antidepressant-like effects on a DRL 72-S schedule.