Nature genetics, 1993-04, Vol.3 (4), p.292-298
1993
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9
- Ist Teil von
- Nature genetics, 1993-04, Vol.3 (4), p.292-298
- Ort / Verlag
- United States
- Erscheinungsjahr
- 1993
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In the human paired box-containing (PAX) gene family, only two members, PAX-3 and PAX-6, which are associated with Waardenburg's syndrome and aniridia, respectively have been mapped to human chromosomes. We have now isolated cosmids for six additional human PAX genes (PAX-1,-2,-5,-7,-8,-9) and a polymerase chain reaction fragment for PAX-4. PAX-9 is a novel family member which is closely related in its paired domain to PAX-1. The chromosomal location of all cloned PAX genes was determined by analysis of somatic cell hybrids and (except PAX-4) by fluorescence in situ hybridization to metaphase chromosomes. PAX-1 and PAX-7 map to chromosomal regions containing previously assigned disease loci.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng0493-292Titel-ID: cdi_proquest_miscellaneous_76303733
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Aniridia - genetics, Base Sequence, Chromosome Mapping, chromosomes, Chromosomes, Human, Pair 14, Cloning, Molecular, Cosmids, DNA Primers, DNA-Binding Proteins - biosynthesis, DNA-Binding Proteins - genetics, gene mapping, genes, Humans, Hybrid Cells, In Situ Hybridization, Fluorescence, Karyotyping, man, Mice, Molecular Sequence Data, PAX gene, PAX9 Transcription Factor, Polymerase Chain Reaction, Sequence Homology, Amino Acid, Transcription Factors - biosynthesis, Transcription Factors - genetics, Waardenburg Syndrome - genetics