Details

Autor(en) / Beteiligte

• Minmin, Shi
• Zhidong, Gu
• Hao, Chen
• Weixia, Zhang
• Baiyong, Shen
• Bing, Chen
• Chuan, Shen
• Xiaxing, Deng
• Xi, Zhan

Titel

Correlation Between Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid in Liver Transplant Patients

Ist Teil von

• Journal of clinical pharmacology, 2010-12, Vol.50 (12), p.1388-1396

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2010

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• This study investigated the relationship between pharmacokinetics and pharmacodynamics of mycophenolic acid (MPA) in liver transplant patients receiving mycophenolate mofetil (MMF). Total and free plasma MPA concentrations were determined by high‐performance liquid chromatography before MMF dose and at 0.5, 1, 1.5, 2, 4, 6, 8, 10, and 12 hours after dosing in 27 patients. The inhibitory capacity of serum MPA on proliferation of CEM cells was monitored at 0, 1, and 2 hours. The concentration of free MPA at 0, 1, and 2 hours (C0h, C1h, C2h) and the area under the concentration‐time curve at 0 to 12 hours (AUC0‐12h) of free MPA were significantly related to those of total MPA (P < .05). C1h and C2h of total and free MPA were conversely related with the rate of proliferation of CEM cells (P < .05). At 1 and 2 hours after an MMF dose, the percentage of CEM cell proliferation was below 40% in the majority of patients compared with the percentage before dosing. Thus, there was a significant relationship between total and free plasma MPA concentrations in liver transplant patients. After MMF dose, the inhibitory capacity of serum MPA on proliferation of CEM cells was enhanced significantly. This effect was related greatly to MPA concentrations.