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Analysis of chickens for recombination within the MHC (B-complex)
Ist Teil von
Tissue antigens, 1985-05, Vol.25 (5), p.278-282
Ort / Verlag
Oxford, UK: Blackwell Publishing Ltd
Erscheinungsjahr
1985
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In an attempt to further map the chicken MHC (the B complex), a systematic search for genetic recombinants within the B complex was performed by serotyping the progeny from F2 crosses of chickens by means of specific anti‐class I, anti‐class II, and anti‐class IV alloantisera.
Two recombinant B‐haplotypes (B21r and B15r) were found by analysing 2,656 F2 chickens representing 5,312 informative typings. In either case, the B‐G (class IV) allele was recombined with both the B‐F and B‐L alleles of the opposite haplotype. MLC typings, tests for direct compatibility by GVH reactions, and absorption analyses confirmed the original serological typing of the two recombinant B haplotypes. No recombination between B‐F (class I) and B‐L (class II) loci was found. This very low frequency of recombination within the B complex as compared with recombination frequencies found in mammalian MHC's is discussed.