Details
- Autor(en) / Beteiligte
- Titel
- Gamma Delta Tocotrienols Reduce Hepatic Triglyceride Synthesis and VLDL Secretion
- Ist Teil von
- Journal of Atherosclerosis and Thrombosis, 2010, Vol.17(10), pp.1019-1032
- Ort / Verlag
- Japan: Japan Atherosclerosis Society
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Aim: Present study aimed to elucidate the suppression of serum lipids by gamma- and delta-tocotrienol (γδT3). Methods: The lipid-lowering effects of γδT3 were investigated using HepG2 liver cell line, hypercholesterolemic mice and borderline-high cholesterol patients. Results: In-vitro results demonstrated two modes of action. First, γδT3 suppressed the upstream regulators of lipid homeostasis genes (DGAT2, APOB100, SREBP1/2 and HMGCR) leading to the suppression of triglycerides, cholesterol and VLDL biosyntheses. Second, γδT3 enhanced LDL efflux through induction of LDL receptor (LDLr) expression. Treatment of LDLr-deficient mice with 1 mg/day (50 mg/kg/day) γδT3 for one-month showed 28%, 19% reduction in cholesterol and triglyceride levels respectively, whereas HDL level was unaltered. The lipid-lowering effects were not affected by alpha-tocopherol (αTP). In a placebo-controlled human trial using 120 mg/day γδT3, only serum triglycerides were lowered by 28% followed by concomitant reduction in the triglyceriderich VLDL and chylomicrons. In contrast, total cholesterol, LDL and HDL remained unchanged in treated and placebo groups. The discrepancies between in-vitro, in-vivo and human studies may be attributed to the differential rates of post-absorptive γδT3 degradation and LDL metabolism. Conclusion: Reduction in triglycerides synthesis and transport may be the primary benefit caused by ingesting γδT3 in human.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1340-3478eISSN: 1880-3873DOI: 10.5551/jat.4911Titel-ID: cdi_proquest_miscellaneous_762274326
- Format
- –
- Schlagworte
- Animals, Antioxidant, Apolipoprotein B-100 - genetics, Apolipoprotein B-100 - metabolism, Blotting, Western, Carcinoma, Hepatocellular - genetics, Carcinoma, Hepatocellular - metabolism, Carcinoma, Hepatocellular - pathology, Cardiovascular, Cell Proliferation, Cells, Cultured, Cholesterol, Chromans - pharmacology, Diacylglycerol O-Acyltransferase - genetics, Diacylglycerol O-Acyltransferase - metabolism, Female, Humans, Hydroxymethylglutaryl CoA Reductases - genetics, Hydroxymethylglutaryl CoA Reductases - metabolism, Lipoproteins, VLDL - metabolism, Liver - cytology, Liver - drug effects, Liver - metabolism, Liver Neoplasms - genetics, Liver Neoplasms - metabolism, Liver Neoplasms - pathology, Male, Mice, Mice, Knockout, Receptors, LDL - physiology, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - genetics, Sterol Regulatory Element Binding Protein 1 - genetics, Sterol Regulatory Element Binding Protein 1 - metabolism, Sterol Regulatory Element Binding Protein 2 - genetics, Sterol Regulatory Element Binding Protein 2 - metabolism, Tocotrienol, Triglycerides, Triglycerides - biosynthesis, Triglycerides - metabolism, Vitamin E, Vitamin E - analogs & derivatives, Vitamin E - pharmacology