Details

Autor(en) / Beteiligte

• McNally, P.G.
• Raymond, N.T.
• Swift, P.G.F.
• Hearnshaw, J.R.
• Burden, A.C.

Titel

Does the Prepubertal Duration of Diabetes Influence the Onset of Microvascular Complications?

Ist Teil von

• Diabetic medicine, 1993-12, Vol.10 (10), p.906-908

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1993

Quelle

MEDLINE

Beschreibungen/Notizen

• This study investigated the relationship between the development of diabetic retinopathy and pubertal status at onset of diabetes in 521 Type 1 diabetic patients diagnosed between 1950 and 1985. Pubertal status was based on age at onset (girls ≧ 11 years and boys ≧ 12 years). Retinopathy (all forms) developed in 112 patients (21.5%; 65 background and 47 proliferative retinopathy). For subjects diagnosed in either the prepubertal or postpuberal period, a similar proportion survived without developing retinopathy for any given duration of diabetes (X2 = 0.3822, p = 0.54). However, if only the postpubertal duration of diabetes is considered, then the proportion of patients surviving without retinopathy was significantly less for those diagnosed in the prepubertal period (X2 = 14.2, p = 0.002). This study suggests that the prepubertal duration of diabetes is an important phase and that the years prior to puberty do contribute to the risk of developing microvascular injury.