Details

Autor(en) / Beteiligte

• Kageyama, Ryoichiro
• Ohkubo, Hiroaki
• Nakanishi, Shigetada

Titel

Induction of rat liver angiotensinogen mRNA following acute inflammation

Ist Teil von

• Biochemical and biophysical research communications, 1985-06, Vol.129 (3), p.826-832

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

1985

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Inflammatory responses of the angiotensinogen mRNA in rat liver and brain were examined by RNA blot-hybridization analysis with use of a cDNA probe specific for rat angiotensinogen. The angiotensinogen mRNA in the liver increased rapidly during the first 5 h following the administration of Escherichia coli lipopolysaccharide, and at maximum level of induction, the mRNA increased approximately 5-fold over its normal level. The levels of the mRNA increased with increasing doses of lipopolysaccharide, the half-maximal dose being approximately 1 μg/100 g body weight. In contrast, no such increase was observed in the brain angiotensinogen mRNA. Thus, the expression of the rat angiotensinogen mRNA is regulated in a tissue-specific manner in response to induction of acute inflammation.