Details

Autor(en) / Beteiligte

• Pfister, C.
• Chabre, M.
• Plouet, J.
• Tuyen, V. V.
• De Kozak, Y.
• Faure, J. P.
• Kühn, H.

Titel

Retinal S Antigen Identified as the 48K Protein Regulating Light-Dependent Phosphodiesterase in Rods

Ist Teil von

• Science (American Association for the Advancement of Science), 1985-05, Vol.228 (4701), p.891-893

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

1985

Quelle

MEDLINE

Beschreibungen/Notizen

• Retinal S antigen chromatographically purified from whole retina, induces experimental autoimmune uveoretinitis in laboratory animals. The 48K protein, a soluble protein found in rod outer segments, is purified through its specific binding to photoexcited rhodopsin and is involved in the quenching of light-induced guanosine 3′,5′-monophosphate-phosphodiesterase activity. Biochemical, immunological, functional, and pathological tests showed that retinal S antigen and the 48K protein are identical.