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Pretransplantation [18‐F]fluorodeoxyglucose positron emission tomography scan predicts outcome in patients with recurrent Hodgkin lymphoma or aggressive non‐Hodgkin lymphoma undergoing reduced‐intensity conditioning followed by allogeneic stem cell transplantation
Cancer, 2010-11, Vol.116 (21), p.5001-5011
Dodero, Anna
Crocchiolo, Roberto
Patriarca, Francesca
Miceli, Rosalba
Castagna, Luca
Ciceri, Fabio
Bramanti, Stefania
Frungillo, Niccolo
Milani, Raffaella
Crippa, Flavio
Fallanca, Federico
Englaro, Emanuela
Corradini, Paolo
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Dodero, Anna
Crocchiolo, Roberto
Patriarca, Francesca
Miceli, Rosalba
Castagna, Luca
Ciceri, Fabio
Bramanti, Stefania
Frungillo, Niccolo
Milani, Raffaella
Crippa, Flavio
Fallanca, Federico
Englaro, Emanuela
Corradini, Paolo
Titel
Pretransplantation [18‐F]fluorodeoxyglucose positron emission tomography scan predicts outcome in patients with recurrent Hodgkin lymphoma or aggressive non‐Hodgkin lymphoma undergoing reduced‐intensity conditioning followed by allogeneic stem cell transplantation
Ist Teil von
Cancer, 2010-11, Vol.116 (21), p.5001-5011
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND: The use of positron emission tomography (PET) scanning in Hodgkin lymphoma (HL) and aggressive non‐Hodgkin lymphoma (HG‐NHL) has recognized prognostic value in patients who are receiving chemotherapy or undergoing autologous stem cell transplantation (SCT). In contrast, the role of PET before reduced‐intensity conditioning (RIC) and followed by allogeneic SCT has not been investigated to date. METHODS: PET was used to assess 80 patients who had chemosensitive disease (34 patients with HG‐NHL and 46 patients with HL) before they underwent allogeneic SCT: 42 patients had negative PET studies, and 38 patients had positive PET studies. Patients underwent allograft from matched related siblings (n = 41) or alternative donors (n = 39). RESULTS: At the time of the last follow‐up, 48 patients were alive (60%), and 32 had died. The 3‐year cumulative incidence of nonrecurrence mortality and disease recurrence was 17% and 40%, respectively. The cumulative incidence of disease recurrence was significantly lower in the PET‐negative patients (25% vs 56%; P = .007), but there was no significant difference between the patients with or without chronic graft‐versus‐host disease (P = .400). The patients who had negative PET studies before undergoing allogenic SCT also had significantly better outcomes in terms of 3‐year overall survival (76% vs 33%; P = .001) and 3‐year progression‐free survival (73% vs 31%; P = .001). On multivariate analysis, overall survival was influenced by PET status (hazard ratio [HR], 3.35), performance status (HR, 5.15), and type of donor (HR, 6.26 for haploidentical vs sibling; HR, 1.94 for matched unrelated donor vs sibling). CONCLUSIONS: The current results indicated that PET scanning appears to be an accurate tool for assessing prognosis in patients who are eligible for RIC allografting. Cancer 2010. © 2010 American Cancer Society. Disease assessment on an [18‐F]fluorodeoxyglucose positron emission tomography (PET) scan before allogeneic stem cell transplantation was capable of predicting long‐term survival in patients with recurrent and chemosensitive Hodgkin lymphoma or aggressive non‐Hodgkin lymphoma, because the patients who had negative PET scans were at lower risk of recurrence and had better progression‐free and overall survival than the patients who had positive PET scans. The predictive value of PET was independent of graft‐versus‐host disease and the graft‐versus‐lymphoma effect.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.25357
Titel-ID: cdi_proquest_miscellaneous_760232802
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
aggressive non‐Hodgkin lymphoma
,
allogeneic transplantation
,
Biological and medical sciences
,
Female
,
Fluorodeoxyglucose F18
,
Graft vs Host Disease - epidemiology
,
Hematologic and hematopoietic diseases
,
Hodgkin lymphoma
,
Humans
,
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
,
Lymphoma, Non-Hodgkin - diagnosis
,
Lymphoma, Non-Hodgkin - mortality
,
Lymphoma, Non-Hodgkin - therapy
,
Male
,
Medical sciences
,
Middle Aged
,
positron emission tomography
,
Positron-Emission Tomography - methods
,
Prognosis
,
Recurrence
,
Retrospective Studies
,
Stem Cell Transplantation
,
Transplantation Chimera
,
Transplantation Conditioning - methods
,
Transplantation, Homologous
,
Treatment Outcome
,
Tumors
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