Details

Autor(en) / Beteiligte

• Dodero, Anna
• Crocchiolo, Roberto
• Patriarca, Francesca
• Miceli, Rosalba
• Castagna, Luca
• Ciceri, Fabio
• Bramanti, Stefania
• Frungillo, Niccolo
• Milani, Raffaella
• Crippa, Flavio
• Fallanca, Federico
• Englaro, Emanuela
• Corradini, Paolo

Titel

Pretransplantation [18‐F]fluorodeoxyglucose positron emission tomography scan predicts outcome in patients with recurrent Hodgkin lymphoma or aggressive non‐Hodgkin lymphoma undergoing reduced‐intensity conditioning followed by allogeneic stem cell transplantation

Ist Teil von

• Cancer, 2010-11, Vol.116 (21), p.5001-5011

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• BACKGROUND: The use of positron emission tomography (PET) scanning in Hodgkin lymphoma (HL) and aggressive non‐Hodgkin lymphoma (HG‐NHL) has recognized prognostic value in patients who are receiving chemotherapy or undergoing autologous stem cell transplantation (SCT). In contrast, the role of PET before reduced‐intensity conditioning (RIC) and followed by allogeneic SCT has not been investigated to date. METHODS: PET was used to assess 80 patients who had chemosensitive disease (34 patients with HG‐NHL and 46 patients with HL) before they underwent allogeneic SCT: 42 patients had negative PET studies, and 38 patients had positive PET studies. Patients underwent allograft from matched related siblings (n = 41) or alternative donors (n = 39). RESULTS: At the time of the last follow‐up, 48 patients were alive (60%), and 32 had died. The 3‐year cumulative incidence of nonrecurrence mortality and disease recurrence was 17% and 40%, respectively. The cumulative incidence of disease recurrence was significantly lower in the PET‐negative patients (25% vs 56%; P = .007), but there was no significant difference between the patients with or without chronic graft‐versus‐host disease (P = .400). The patients who had negative PET studies before undergoing allogenic SCT also had significantly better outcomes in terms of 3‐year overall survival (76% vs 33%; P = .001) and 3‐year progression‐free survival (73% vs 31%; P = .001). On multivariate analysis, overall survival was influenced by PET status (hazard ratio [HR], 3.35), performance status (HR, 5.15), and type of donor (HR, 6.26 for haploidentical vs sibling; HR, 1.94 for matched unrelated donor vs sibling). CONCLUSIONS: The current results indicated that PET scanning appears to be an accurate tool for assessing prognosis in patients who are eligible for RIC allografting. Cancer 2010. © 2010 American Cancer Society. Disease assessment on an [18‐F]fluorodeoxyglucose positron emission tomography (PET) scan before allogeneic stem cell transplantation was capable of predicting long‐term survival in patients with recurrent and chemosensitive Hodgkin lymphoma or aggressive non‐Hodgkin lymphoma, because the patients who had negative PET scans were at lower risk of recurrence and had better progression‐free and overall survival than the patients who had positive PET scans. The predictive value of PET was independent of graft‐versus‐host disease and the graft‐versus‐lymphoma effect.