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Tracing iron and transferrin in the macrophage by visual means
American journal of hematology, 1993-11, Vol.44 (3), p.179-186
Haurani, Farid I.
Ryter, Antoinette
1993
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Haurani, Farid I.
Ryter, Antoinette
Titel
Tracing iron and transferrin in the macrophage by visual means
Ist Teil von
American journal of hematology, 1993-11, Vol.44 (3), p.179-186
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1993
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
The purpose of the study was to investigate the movement of iron and transferrin in the macrophage using light and electron microscopy. First, depicted here are the phagocytosis of antibody sensitized murine red cells by the murine bone marrow derived macrophage and the formation of red cell phagosomes. Second, we show the fusion of the lysosomes with the red cell phagosome to form a lysophagosome and the lysis of the red cell using acid phosphatase as a lysosome marker. Third, by autoradiography, the presence of 55Fe silver grains in the phagocytosed red cells and its delivery to the organelles of the macrophage are demonstrated. Fourth a transferrin species is shown in red cells of all ages, in the phagocytosed as well as the non‐phagocytosed, and in the phagocytosed as well as the non‐phagocytosed, and in the macrophage itself. Transferrin was detected using immunogold and fluorescence labelling. These studies suggest that iron, using vesicles as means of transport, moves from the effete red cells inside the macrophage to the outside possibly bound to transferrin. © 1993 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0361-8609
eISSN: 1096-8652
DOI: 10.1002/ajh.2830440308
Titel-ID: cdi_proquest_miscellaneous_76009615
Format
–
Schlagworte
Animals
,
Autoradiography
,
Biological and medical sciences
,
Biological Transport
,
Bone Marrow Cells
,
Cell physiology
,
electron microscopy
,
Erythrocytes
,
Female
,
Fluorescent Antibody Technique
,
Fundamental and applied biological sciences. Psychology
,
Immunohistochemistry
,
iron
,
Iron - metabolism
,
Iron Radioisotopes
,
macrophage
,
Macrophages - metabolism
,
Macrophages - ultrastructure
,
Membrane and intracellular transports
,
Mice
,
Mice, Inbred C57BL
,
Microscopy, Electron
,
Molecular and cellular biology
,
Organelles - metabolism
,
Phagocytosis
,
transferrin
,
Transferrin - metabolism
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