Details

Autor(en) / Beteiligte

• Leon, Martin B
• Smith, Craig R
• Mack, Michael
• Miller, D. Craig
• Moses, Jeffrey W
• Svensson, Lars G
• Tuzcu, E. Murat
• Webb, John G
• Fontana, Gregory P
• Makkar, Raj R
• Brown, David L
• Block, Peter C
• Guyton, Robert A
• Pichard, Augusto D
• Bavaria, Joseph E
• Herrmann, Howard C
• Douglas, Pamela S
• Petersen, John L
• Akin, Jodi J
• Anderson, William N
• Wang, Duolao
• Pocock, Stuart

Titel

Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery

Ist Teil von

• The New England journal of medicine, 2010-10, Vol.363 (17), p.1597-1607

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Patients with aortic stenosis underwent transfemoral transcatheter implantation of a balloon-expandable bovine pericardial aortic valve. One-year mortality was lower with the balloon-expandable valve than with standard therapy, but the risk of stroke was higher. Aortic stenosis is an insidious disease with a long latency period 1 followed by rapid progression after the appearance of symptoms, 2 – 5 resulting in a high rate of death (approximately 50% in the first 2 years after symptoms appear) among untreated patients. 1 , 6 – 8 Surgical replacement of the aortic valve reduces symptoms and improves survival in patients with aortic stenosis, 9 – 11 and in the absence of serious coexisting conditions, the procedure is associated with low operative mortality. 12 , 13 However, in clinical practice, at least 30% of patients with severe symptomatic aortic stenosis do not undergo surgery for replacement of the aortic . . .