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Bulletin of environmental contamination and toxicology, 1985-01, Vol.34 (1), p.114-120
1985
Volltextzugriff (PDF)

Details

Autor(en) / Beteiligte
Titel
Effect of aroclor 1254 on the biological fate of 2,6-dimethylnaphthalene in Coho salmon (Oncorhynchus kisutch)
Ist Teil von
  • Bulletin of environmental contamination and toxicology, 1985-01, Vol.34 (1), p.114-120
Ort / Verlag
New York, NY: Springer-Verlag
Erscheinungsjahr
1985
Quelle
springer (창간호~2014)
Beschreibungen/Notizen
  • Coho salmon were injected (i.p.) with 5 or 100 mg PCB per kg body weight four days prior to force-feeding with 5.7 mg radio-labelled 2,6-dimethylnaphthalene (DMN) per kg. Tissues were analysed 24, 48, 96 and 168 hours after DMN administration. In all groups, DMN-derived radioactivity was highest in bile followed by liver, muscle and brain, then blood. The overall effect of PCB pretreatment was increased levels of DMN metabolites in the bile resulting in generally lower levels of DMN or its derivatives in extrahepatic tissues. Despite the fact that there was no apparent increase in radioactivity in the liver of PCB-treated fish, results suggested that PCB did induce the hepatic metabolism of DMN but that the metabolites were then readily excreted into the bile.

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