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Developmental changes in the acetylcholine influence on heart muscle of Rana catesbeiana: in situ and in vitro effects
The Journal of experimental zoology, 1993-09, Vol.267 (1), p.1-8
Pelster, Bernd
Burggren, Warren W.
Petrou, Steven
Wahlqvist, Inger
1993
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Pelster, Bernd
Burggren, Warren W.
Petrou, Steven
Wahlqvist, Inger
Titel
Developmental changes in the acetylcholine influence on heart muscle of Rana catesbeiana: in situ and in vitro effects
Ist Teil von
The Journal of experimental zoology, 1993-09, Vol.267 (1), p.1-8
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1993
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The influence of acetylcholine (ACh) on cardiac performance of larval (Taylor Kollros [TK] stages II‐XVIII) and postmetamorphic (3–609 g) Rana catesbeiana was analyzed in situ (circulatory system intact) and in vitro (isolated heart or ventricular strip preparations). Topical application of ACh to the heart in situ resulted in a dose‐dependent decrease in heart rate and in a slight decrease in systolic ventricular pressure in all developmental stages. Injection of acetylcholine in to the ventricle lumen in situ caused a dose‐dependent transient decrease in systolic ventricular pressure, with little heart rate effect. Intraventricular ACh injection also changed the hemodynamic coupling between ventricle and conus arteriosus, generating a biphasic pressure profile in the conus due to sequential contractions of the ventricle and of the conus. In situ the sensitivity of the ventricle to ACh decreased during larval development, with the lowest sensitivity in small postmetamorphic adults. ACh applied in vitro to cardiac muscle strips or small hearts produced a negative inotropic effect. The ACh dose necessary to induce a 50% reduction in muscle strip contraction force in vitro decreased substantially during larval development, indicating an increase in ACh sensitivity with development. The effects of ACh both in vitro and in situ were diminished or eliminated by topical application or injection of atropine, suggesting the presence of muscarinic cholinergic receptors. After preincubation with the acetylcholinesterase blocker eserine, injection of ACh in to the conus arteriosus decreased systolic ventricular pressure with a delay of 4–10 seconds, probably representing the minimum blood circulation time. The observed inotropic and chronotropic responses result from the action of ACh on cardiac muscle, primarily affecting systolic ventricular pressure, and on the cardiac pacemaker, mainly influencing heart rate. These responses occur as early as TK, stage II, indicating a well‐developed set of mechanisms to regulate cardiovascular performance early in development. © 1993 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0022-104X
eISSN: 1097-010X
DOI: 10.1002/jez.1402670102
Titel-ID: cdi_proquest_miscellaneous_75976199
Format
–
Schlagworte
Acetylcholine - pharmacology
,
Administration, Topical
,
Animals
,
Biological and medical sciences
,
Blood Pressure
,
Coronary Circulation
,
Fundamental and applied biological sciences. Psychology
,
Heart
,
Heart - embryology
,
Heart - growth & development
,
Heart - physiology
,
Injections, Intraventricular
,
Larva
,
Rana catesbeiana
,
Vertebrates: cardiovascular system
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