Details

Autor(en) / Beteiligte

• Franklin, Christopher S
• Aulchenko, Yurii S
• Huffman, Jennifer E
• Vitart, Veronique
• Hayward, Caroline
• Polašek, Ozren
• Knott, Sara
• Zgaga, Lina
• Zemunik, Tatijana
• Rudan, Igor
• Campbell, Harry
• Wright, Alan F
• Wild, Sarah H
• Wilson, James F

Titel

The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis

Ist Teil von

• Annals of human genetics, 2010-11, Vol.74 (6), p.471-478

Ort / Verlag

England

Erscheinungsjahr

2010

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Genome-wide association (GWA) studies have identified around 20 common genetic variants influencing the risk of type 2 diabetes (T2D). Likewise, a number of variants have been associated with diabetes-related quantitative glycaemic traits, but to date the overlap between these genes and variants has been low. The majority of genetic studies have focused on fasting plasma glucose levels; however, this measure is highly variable. We have conducted a GWA meta-analysis of glycated haemoglobin (HbA₁(C) ) levels within three healthy nondiabetic populations. This phenotype provides an estimate of mean glucose levels over 2-3 months and is a more stable predictor of future diabetes risk. Participants were from three isolated populations: the Orkney Isles in the north of Scotland, the Dalmatian islands of Vis, and Korčula in Croatia (total of 1782 nondiabetic subjects). Association was tested in each population and results combined by meta-analysis. The strongest association was with the TCF7L2 gene (rs7903146, P= 1.48 × 10⁻⁷). This is also the strongest common genetic risk factor for T2D but it has not been identified in previous genome-wide studies of glycated haemoglobin.