Details

Autor(en) / Beteiligte

• Wilber, David J.
• Lynch, Joseph J.
• Montgomery, Daniel
• Lucchesi, Benedict R.

Titel

Postinfarction sudden death: Significance of inducible ventricular tachycardia and infarct size in a conscious canine model

Ist Teil von

• The American heart journal, 1985, Vol.109 (1), p.8-18

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

1985

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The relationship between inducible ventricular tachycardia in the convalescent phase of myocardial infarction and subsequent spontaneous ventricular fibrillation is uncertain. Thirty conscious instrumented dogs underwent programmed ventricular stimulation 5 days after anterior infarction; 15 had inducible ventricular tachycardia and 15 were noninducible. Following programmed ventricular stimulation, the application of a 150 uA current to the intima of the proximal circumflex artery initiated intimal damage, thrombosis, and acute ischemia of the posterolateral wall. After 20 minutes of ischemia, 73% inducible and 15% noninducible anlmals developed ventricular fibrillation ( p < 0.005) without previous hypotension. At 24 hours, 7% inducible and 85% noninducible animals survived ( p < 0.001). Anterior infarct size (percentage of left ventricular mass) was much larger in inducible (24.7 ± 1.7%) than in noninducible (5.3 ± 1.1%) ( p < 0.001) animals. Inducible ventricular tachycardia following infarction was highly predictive of spontaneous ventricular fibrillation during a later ischemic episode in this model. The mass of previously injured myocardium was a critical determinant of both.