Leukemia research, 1993-08, Vol.17 (8), p.721-723
1993
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Details
- Autor(en) / Beteiligte
- Titel
- Rearrangement of the N- myc oncogene in acute leukemias: A case report
- Ist Teil von
- Leukemia research, 1993-08, Vol.17 (8), p.721-723
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 1993
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Rearrangements of the N-myc oncogene have not been described in the literature. The authors present a case of ANLL with the N-myc gene rearranged out of 16 ANLLs and 11 ALLs. While the proportion of the blast cells in the case reported was 85%, the rearranged gene gave a hybridization band which was less intense than that of the germline band, making it probable that this gene rearrangement is present in a leukemia subclone. The c-myc oncogene as well as Ig and TcR genes were in germline configurations. The presence of the rearranged N-myc in the reported case could imply an alternative mechanism of mutation of this oncogene in the pathogenesis of hematological malignancies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0145-2126eISSN: 1873-5835DOI: 10.1016/0145-2126(93)90081-UTitel-ID: cdi_proquest_miscellaneous_75912726
- Format
- –
- Schlagworte
- acute non-lymphoblastic leukemia, Aged, Antigens, CD - blood, Biological and medical sciences, digoxigenin, DNA Probes, DNA, Neoplasm - genetics, DNA, Neoplasm - isolation & purification, Female, gene N-myc, Gene Rearrangement, Genes, myc, Hematologic and hematopoietic diseases, HLA-DR Antigens - blood, Humans, Leukemia, Myeloid, Acute - blood, Leukemia, Myeloid, Acute - genetics, Leukemia, Myeloid, Acute - immunology, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Medical sciences, Monocytes - physiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics, Restriction Mapping