Details

Autor(en) / Beteiligte

• Lucarelli, Guido
• Galimberti, Maria
• Polchi, Paola
• Angelucci, Emanuele
• Baronciani, Donatella
• Giardini, Claudio
• Andreani, Marco
• Agostinelli, Fabrizio
• Albertini, Federico
• Clift, Reginald A

Titel

Marrow Transplantation in Patients with Thalassemia Responsive to Iron Chelation Therapy

Ist Teil von

• The New England journal of medicine, 1993-09, Vol.329 (12), p.840-844

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1993

Quelle

MEDLINE

Beschreibungen/Notizen

• Marrow transplantation from HLA-identical related donors is an accepted treatment for patients with homozygous beta-thalassemia, 1 , 2 but there remain questions about the selection of patients and the timing of transplantation. A system of classifying patients that has prognostic value has been described and tested in patients younger than 16 years of age. Three classes of patients can be identified on the basis of the inadequacy of iron chelation with conventional therapy, the presence of hepatomegaly, and the presence of portal fibrosis in the liver: patients in class 1 have none of the characteristics, patients in class 2 have one or . . .