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We investigated whether different procedures during general anaesthesia alter platelet activation in vivo and/ or activate coagulation and fibrinolysis. Forty‐one healthy adult patients, scheduled for elective ophthalmic surgery under general anaesthesia, were studied with regard to changes of plasma beta‐thromboglobulin (βG, index of platelet activation), thrombin‐antithrombin Ill‐complex (TAT, index of activation of coagulation) and d‐dimer (index of fibrinolysis) during anaesthesia. The patients underwent either inhalation anaesthesia with enflurane and nitrous oxide or balanced anaesthesia with enflurane (0.5% end‐tidal concentration) and alfentanil. Ten minutes after intubation the βTG level was significantly reduced compared to the preoperative value in both general anaesthesia groups. Balanced anaesthesia caused a moderate but significant increase of TAT values at 10 min after extubation. No significant change in d‐dimer levels was seen. Presuming a minimal effect of the surgical procedure on the determined variables, we conclude that none of the anaesthetic procedures induces platelet activation and fibrinolysis. The clinical relevance of the moderate coagulation activation during balanced anaesthesia remains to be investigated.