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BibTeX
Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma
Journal of surgical oncology, 1993-08, Vol.53 (4), p.252-255
Gomella, Leonard G.
Ehya, Hormoz
Steinberg, Seth M.
Rupp, Michael
Merino, Maria
Robertson, Cary
Linehan, W. Marston
1993
Details
Autor(en) / Beteiligte
Gomella, Leonard G.
Ehya, Hormoz
Steinberg, Seth M.
Rupp, Michael
Merino, Maria
Robertson, Cary
Linehan, W. Marston
Titel
Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma
Ist Teil von
Journal of surgical oncology, 1993-08, Vol.53 (4), p.252-255
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
1993
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Adoptive immunotherapy using interleukin‐2 (IL‐2) based therapy can result in marked tumor regression in some patients with metastatic renal cell carcinoma. DNA flow cytometry has not been previously studied as a predictor of outcome of this therapy. Archival paraffin embedded tumors were studied in 23 IL‐2 treated patients with metastatic renal cell carcinoma. Eleven patients were complete responders (CR) and 12 were nonresponders (NR). In the CR group, 4/11 (40%) were diploid and 7/11 (60%) were aneuploid. In the NR group, 9/12 (75%) were diploid and 3/12 (25%) were aneuploid. Although there was a trend that patients with an aneuploid DNA pattern were more likely to undergo a complete response, ploidy pattern alone was not significantly predictive of response (p2 = 0.10, Fischer's exact test). When combining ploidy pattern with other variables that were predictive for complete response, such as good performance status and a higher pretreatment weight, prediction of complete response was not improved by including ploidy. This preliminary report suggests that DNA ploidy does not appear to provide any additional information concerning responsiveness to IL‐2 based immunotherapy beyond that obtained by performance status and pretreatment weight in this patient population. © 1993 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0022-4790
eISSN: 1096-9098
DOI: 10.1002/jso.2930530413
Titel-ID: cdi_proquest_miscellaneous_75880764
Format
–
Schlagworte
Biological and medical sciences
,
Carcinoma, Renal Cell - genetics
,
Carcinoma, Renal Cell - therapy
,
DNA, Neoplasm - genetics
,
Flow Cytometry
,
Humans
,
interleukin-2
,
Interleukin-2 - therapeutic use
,
Kidney Neoplasms - genetics
,
Kidney Neoplasms - therapy
,
Kidneys
,
Killer Cells, Lymphokine-Activated - transplantation
,
Lymphocytes, Tumor-Infiltrating - transplantation
,
Medical sciences
,
Nephrology. Urinary tract diseases
,
Ploidies
,
Predictive Value of Tests
,
renal cell carcinoma
,
Treatment Outcome
,
Tumors of the urinary system
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