Details

Autor(en) / Beteiligte

• Woo, J.
• Ho, S.C.
• Wong, S.L.
• Woo, K.S.
• Tse, C.Y.
• Chan, K.K.
• Kay, C.S.
• Mak, W.P.
• Cheung, K.O.
• Lam, C.W.K.
• Donnan, S.P.B.

Titel

Lipids, lipoproteins and other coronary risk factors in Chinese male survivors of myocardial infarction

Ist Teil von

• International journal of cardiology, 1993-06, Vol.39 (3), p.195-202

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

1993

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Objective: To assess the importance of an abnormal lipid profile as a risk factor in relation to non-biochemical risk factors, and to define the risk levels for lipid, lipoprotein and apolipoprotein in a Chinese population. Patients and Methods: Serum lipids, lipoproteins, apolipoproteins and other cardiovascular risk factors were studied in 89 Chinese men 3 months after acute myocarial infarction and 56 controls. Results: Cases had higher mean total cholesterol (TC), LDL- and VLDL-cholesterol, triglycerides and apolipoprotein B (Apo B), and lower mean HDL-cholesterol and apolipoprotein AI (Apo AI). Mean BMI was also higher, as was the prevalence of smokers and subjects with a history of hypertension. In univariate analysis, the odds ratios for TG ≥ 1.6 mmol/l, LDL-cholesterol ≥ 4.1 mmol/l, VLDL-cholesterol ≥ 0.73 mmol/l, Apo B ≥ 104 mg/dl were of the same order of magnitude as being a current smoker, having a BMI ≥ 24.3 kg/m 2, and a history of a hypertension. High HDL-cholesterol (≥ 1.39 mmol/l) and Apo AI (≥ 139 mg/dl) were protective factors. The odds ratios for successively higher quartile values of cholesterol were not statistically significant. Multiple logistic regression identified smoking habit, history of hypertension, obesity, high Apo B and low Apo AI concentrations as independent risk factors for myocardial infarction. Conclusions: In a Chinese population, low serum Apo AI and high Apo B are risk factors for myocardial infarction of a comparable magnitude to smoking, hypertension and obesity.