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Induction of Apoptosis by the Low-Affinity NGF Receptor
Ist Teil von
Science (American Association for the Advancement of Science), 1993-07, Vol.261 (5119), p.345-348
Ort / Verlag
Washington, DC: American Society for the Advancement of Science
Erscheinungsjahr
1993
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to Trk A, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75$^{NGFR}$, remains uncertain. Expression of p75$^{NGFR}$ induced neural cell death constitutively when p75$^{NGFR}$ was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75$^{NGFR}$. Thus, expression of p75$^{NGFR}$ may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75$^{NGFR}$ has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40.