Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3647-3650
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Novel chromene derivatives as TNF-α inhibitors
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3647-3650
- Ort / Verlag
- Oxford: Elsevier
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A novel series of chromene-based TNF-alpha inhibitors is described. These chromene derivatives inhibit bacterial lipopolysaccharide (LPS) stimulated production of TNF-alpha from human peripheral blood mononuclear cells (PBMC). Additionally, these compounds inhibit NF-kB mediated transcription activation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2003.08.025Titel-ID: cdi_proquest_miscellaneous_75763873
- Format
- –
- Schlagworte
- Benzopyrans - pharmacology, Biological and medical sciences, Bones, joints and connective tissue. Antiinflammatory agents, Enzyme-Linked Immunosorbent Assay, Humans, Indicators and Reagents, Lipopolysaccharides - antagonists & inhibitors, Medical sciences, Monocytes - drug effects, Monocytes - metabolism, NF-kappa B - antagonists & inhibitors, Pharmacology. Drug treatments, Structure-Activity Relationship, Transcriptional Activation - drug effects, Tumor Necrosis Factor-alpha - antagonists & inhibitors