Details

Autor(en) / Beteiligte

• Kochs, Eberhard
• Hoffman, William E
• Werner, Christian
• Albrecht, Ronald F
• Esch, Jochen Schulte am

Titel

Cerebral Blood Flow Velocity in Relation to Cerebral Blood Flow, Cerebral Metabolic Rate for Oxygen, and Electroencephalogram Analysis During Isoflurane Anesthesia in Dogs

Ist Teil von

• Anesthesia and analgesia, 1993-06, Vol.76 (6), p.1222-1226

Ort / Verlag

Hagerstown, MD: International Anesthesia Research Society

Erscheinungsjahr

1993

Quelle

MEDLINE

Beschreibungen/Notizen

• The purpose of this study was to correlate changes in cerebral blood flow velocity (Vmean) with cerebral blood flow (CBF) during isoflurane anesthesia in dogs. The relation between cerebral oxygen consumption (CMRO2) and electroencephalogram (EEG) analysis also was investigated. Blood flow velocity was measured in the middle cerebral artery using a pulsed transcranial Doppler (TCD). CBF was measured with radioactive microspheres. EEG was measured over both hemispheres and median EEG frequency (median frequency) was calculated after fast Fourier transformation. Baseline anesthesia was maintained with 50% nitrous oxide in oxygen and 50 μg·kg·h fentanyl. Animals of Group I (control, n = 6) were not given isoflurane. Data were recorded at baseline, and at 30, 60, and 90 min. There was no significant change in any variable over time. In Group II (n = 7), data were recorded at baseline and at 1%, 2%, and 3% end-tidal isoflurane. Mean arterial pressure was maintained at baseline levels by phenylephrine infusion. CBF increased from 70.8 ± 10.6 mL·100 g·min at baseline to 146.1 ± 36.9 mL·100 g·min with 3% isoflurane (P < 0.01). Vmean increased from 38.3 ± 6.7 cm/s to 65.6 ± 9.7 cm/s (P < 0.01). The correlation between relative changes in CBF and Vmean was r = 0.94 (P < 0.01). With 1% isoflurane the EEG shifted to slow-wave, high-voltage activity, and median frequency decreased from 5.9 ± 0.7 Hz to 1.4 ± 0.4 Hz (P < 0.05). Median frequency was not decreased further during 2% and 3% isoflurane anesthesia. In contrast, CMRO2 did not change with 1% isoflurane, but decreased 50% with 3% isoflurane (P < 0.05). The correlation between median frequency and CMRO2 was not significant (r = 0.19, P > 0.05). A negative correlation was found between periods of electrical silence and CMRO2 (r = −0.73, P < 0.05). We conclude that relative increases in CBF can be assessed by Vmean. In contrast, even though EEG patterns indicate changes in anesthetic depth, depression of cerebral metabolism is not closely related to changes in median frequency.(Anesth Analg 1993;76:1222-6)