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Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck
International journal of cancer, 2003-11, Vol.107 (3), p.401-406
Koskinen, Walter J.
Chen, Ren Wei
Leivo, Ilmo
Mäkitie, Antti
Bäck, Leif
Kontio, Risto
Suuronen, Riitta
Lindqvist, Christian
Auvinen, Eeva
Molijn, Anco
Quint, Wim G.
Vaheri, Antti
Aaltonen, Leena‐Maija
2003
Details
Autor(en) / Beteiligte
Koskinen, Walter J.
Chen, Ren Wei
Leivo, Ilmo
Mäkitie, Antti
Bäck, Leif
Kontio, Risto
Suuronen, Riitta
Lindqvist, Christian
Auvinen, Eeva
Molijn, Anco
Quint, Wim G.
Vaheri, Antti
Aaltonen, Leena‐Maija
Titel
Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck
Ist Teil von
International journal of cancer, 2003-11, Vol.107 (3), p.401-406
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Link zum Volltext
Quelle
Electronic Journals Library
Beschreibungen/Notizen
Fresh‐frozen biopsies were obtained from 61 patients at diagnosis of squamous cell carcinoma of the head and neck (HNSCC) for study of the prevalence and physical status of human papillomavirus (HPV) DNA. The frequency of HPV DNA and genotypes were determined by SPF10 PCR screening with a general probe hybridization and INNO‐LiPA HPV genotyping assay. In addition, a single‐phase PCR with primers FAP 59/64 and a nested PCR with primers CP 65/70 and CP 66/69 served to detect particularly cutaneous HPV types. By the sensitive SPF10 PCR and INNO‐LiPA assay, 37 of 61 (61%) samples were positive for HPV. HPV‐16 was the most frequently detected type (31 of 37, 84%). Multiple infections were found in 8 of 37 (22%) of the HPV‐positive samples, and co‐infection by HPV‐16 and HPV‐33 was predominant. No cutaneous HPV types were detected. Patients with HPV‐positive tumors had similar prognosis as those with HPV‐negative ones. Real‐time PCR analysis of the HPV‐16 positive samples indicated the presence of integrated (11 of 23, 48%), episomal (8 of 23, 35%) and mixed forms (4 of 23, 17%) of HPV DNA. The viral load of HPV DNA exhibited large variation. The median copy numbers of E6 DNA in tonsillar specimens were approximately 80,000 times higher than that in nontonsillar HNSCC ones. Patients with episomal viral DNA were more frequently found to have large (T3–T4) tumors at diagnosis than were those with integrated or mixed forms. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.11381
Titel-ID: cdi_proquest_miscellaneous_75717786
Format
–
Schlagworte
Adult
,
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
Carcinoma, Squamous Cell - virology
,
DNA, Viral - analysis
,
DNA-Binding Proteins
,
Female
,
Head and Neck Neoplasms - virology
,
HPV
,
Humans
,
Male
,
Medical sciences
,
Middle Aged
,
Oncogene Proteins, Viral - genetics
,
Otorhinolaryngology (head neck, general aspects and miscellaneous)
,
Otorhinolaryngology. Stomatology
,
Papillomaviridae - isolation & purification
,
Polymerase Chain Reaction
,
squamous cell carcinoma of the head and neck
,
Tumors
,
Viral Load
,
viral physical status
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