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Molecular pathology of atypical polypoid adenomyoma of the uterus
Ist Teil von
Human pathology, 2003-08, Vol.34 (8), p.784-788
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
2003
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Atypical polypoid adenomyoma (APA) is an uncommon and benign tumor of the uterus. In some patients, however, APA has been found to coexist with or to precede the development of an endometrioid adenocarcinoma similarly to complex endometrial hyperplasia. The molecular changes underlying the progression from APA to adenocarcinoma are unknown. DNA from paraffin-embedded tissue of 6 APAs was evaluated for microsatellite instability (MI),
MLH-
1 promoter hypermethylation, and
CTNNB-
1 mutations. Tissue sections were also subjected to MLH-1, MSH-2, and β-catenin immunostaining. MI was not detected in any case. Two tumors exhibited
MLH-
1 promoter hypermethylation and showed focal negative MHL-1 immunostaining; 1 of these showed marked architectural complexity and cellular pleomorphism. Five cases presented β-catenin nuclear immunoreactivity, but none of them had
CTNNB-
1 mutations. The results of this study suggest that APA and complex endometrial hyperplasia may share some molecular alterations. Some APAs exhibit
MLH-
1 promoter hypermethylation with focal lack of MLH-1 immunostaining, a molecular abnormality involved in the transition from complex atypical hyperplasia to endometrioid adenocarcinoma.