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A polymorphic system related to but genetically independent of the chicken major histocompatibility complex
Ist Teil von
Immunogenetics (New York), 1993-02, Vol.37 (6), p.408-414
Ort / Verlag
Heidelberg: Springer
Erscheinungsjahr
1993
Link zum Volltext
Quelle
SpringerLink Journals
Beschreibungen/Notizen
Analyses of the major histocompatibility complex (Mhc) in chickens have shown inconsistencies between serologically defined haplotypes and haplotypes defined by the restriction fragment patterns of Mhc class I and class II genes in Southern hybridizations. Often more than one pattern of restriction fragments for Mhc class I and/or class II genes has been found among DNA samples collected from birds homozygous for a single serologically defined B haplotype. Such findings have been interpreted as evidence for variability within the Mhc haplotypes of chickens not detected previously with serological methods. In this study of a fully pedigreed family over three generations, the heterogeneity observed in restriction fragment patterns was found to be the result of the presence of a second, independently segregating polymorphic Mhc-like locus, designated Rfp-Y. Three alleles (haplotypes) are identified in this new system.