Details

Autor(en) / Beteiligte

• Goldman, Ira F.
• Qari, Shoukat H.
• Millet, Pascal G.
• Collins, William E.
• Lal, Altaf A.

Titel

Circumsporozoite protein gene of Plasmodium simium, a Plasmodium vivax-like monkey malaria parasite

Ist Teil von

• Molecular and biochemical parasitology, 1993, Vol.57 (1), p.177-180

Ort / Verlag

Shannon: Elsevier B.V

Erscheinungsjahr

1993

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The circumsporozoite (CS) protein, a species-specific sporozoite surface protein and a vaccine candidate antigen, has been characterized from malaria parasites that naturally cause infections in humans, monkeys and chimpanzees. Plasmodium simium is a nonhuman malaria parasite both morphologically and biologically similar to the human malaria parasite Plasmodium vivax. . simium malaria parasites naturally infect black howler monkeys (Alouatta fusca ) and woolly spider monkeys (Brachyteles arachnoides ) in a small area of Brazil. Because of the discrepancy of the infectivity of P. simium sporozoites and of the morphologic and biologic similarities between P. simium and P. vivax , we studied the CS protein of P. simium parasites as an avenue to understand the relationships between these two malaria parasites.