Details

Autor(en) / Beteiligte

• Chung, Wou Young
• Sun, Joo Sung
• Park, Joo Hun
• Lee, Hye Lim
• Lee, Keu Sung
• Kim, Young Sun
• Sheen, Seung Soo
• Park, Kyung Joo
• Hwang, Sung Chul
• Lee, Kyi Beom
• Park, Kwang Joo

Titel

Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia

Ist Teil von

• Respiratory medicine, 2010-11, Vol.104 (11), p.1722-1728

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2010

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Summary Backgrounds Epithelial cell apoptosis plays an important role in the pathogenesis of idiopathic interstitial pneumonia (IIP). Methods Serum levels of caspase-cleaved cytokeratin-18 (M30) were measured in 55 patients with IIP and 34 healthy controls using enzyme-linked immunosorbent assays. The IIP cases included usual interstitial pneumonia (UIP; n  = 30), nonspecific interstitial pneumonia (NSIP; n  = 15), and cryptogenic organizing pneumonia (COP; n  = 10). The radiological scoring was performed based on high-resolution computed tomography (HRCT) findings. Results Patients with IIP had higher serum M30 levels than did the control group (178.6 ± 91.5 vs. 113.7 ± 46.8 U/L, p  < 0.05). Among IIP patients, COP patients had higher serum M30 levels than did UIP or NSIP patients (264.9 ± 132.7, 139.2 ± 49.7, and 201.2 ± 81.1 U/L, respectively; COP vs. UIP, p  < 0.01). Serum M30 levels were negatively correlated with forced vital capacity (FVC; rs  = −0.31), percent-predicted FVC (FVC%; rs  = −0.38), and percent-predicted forced expiratory volume in 1 s (FEV1 %; rs  = −0.36). Serum M30 levels were correlated with radiological ground-glass opacity scores ( rs  = 0.61). Conclusion The epithelial apoptosis marker serum level was correlated with IIP clinical status and is a potential marker to assess IIP.