UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 7 von 9
Datensatz exportieren als...
BibTeX
Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas
Head & neck, 2010-10, Vol.32 (10), p.1354-1362
Hannisdal, Kirsten
Burum-Auensen, Espen
Schjølberg, Aasa
De Angelis, Paula M.
Clausen, Ole Petter F.
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Hannisdal, Kirsten
Burum-Auensen, Espen
Schjølberg, Aasa
De Angelis, Paula M.
Clausen, Ole Petter F.
Titel
Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas
Ist Teil von
Head & neck, 2010-10, Vol.32 (10), p.1354-1362
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
MEDLINE
Beschreibungen/Notizen
Background. Spindle checkpoint proteins such as Mad2 and BubR1 are important for chromosome segregation during mitosis. The aim of the present study was to examine their possible impact on prognosis in tonsillar carcinomas and their relation to clinical variables, the prevalence of human papillomavirus (HPV), p53 status, and Ki‐67 positivity. Methods. We examined the expression of Mad2 and BubR1 by immunohistochemistry on tissue microarrays from 105 patients with tonsillar carcinomas. Results. BubR1 and Mad2 were both expressed in tonsillar carcinomas. Expression of BubR1 was a significant prognostic factor in univariate survival analysis. In multivariate analyses, BubR1 was a significant prognostic factor together with stage, age, and HPV status p < .01), whereas Mad2 did not show any significant correlations. Conclusion. We have shown that BubR1 expression is a novel and strong prognostic factor in tonsillar carcinomas, giving additional information to the TNM stage and other known prognostic factors. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Sprache
Englisch
Identifikatoren
ISSN: 1043-3074
eISSN: 1097-0347
DOI: 10.1002/hed.21342
Titel-ID: cdi_proquest_miscellaneous_755400601
Format
–
Schlagworte
Age Factors
,
Biological and medical sciences
,
BubR1
,
Calcium-Binding Proteins - metabolism
,
Carcinoma, Squamous Cell - metabolism
,
Carcinoma, Squamous Cell - mortality
,
Carcinoma, Squamous Cell - pathology
,
Cell Cycle Proteins - metabolism
,
Female
,
Humans
,
Immunohistochemistry
,
Mad2 Proteins
,
Male
,
Medical sciences
,
Microarray Analysis
,
Middle Aged
,
Otorhinolaryngology. Stomatology
,
p53
,
Papillomavirus Infections - epidemiology
,
Prognosis
,
prognostic factor
,
Protein-Serine-Threonine Kinases - metabolism
,
Repressor Proteins - metabolism
,
spindle checkpoint proteins
,
tonsillar carcinomas
,
Tonsillar Neoplasms - metabolism
,
Tonsillar Neoplasms - mortality
,
Tonsillar Neoplasms - pathology
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX