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The treatment of acute liver failure with fractionated plasma separation and adsorption system: Experience in 85 applications
Journal of clinical apheresis, 2010, Vol.25 (4), p.195-201
Şentürk, Evren
Esen, Figen
Özcan, Perihan E.
Rifai, Kinan
Pinarbaşi, Binnur
Çakar, Nahit
Telci, Lutfi
2010
Details
Autor(en) / Beteiligte
Şentürk, Evren
Esen, Figen
Özcan, Perihan E.
Rifai, Kinan
Pinarbaşi, Binnur
Çakar, Nahit
Telci, Lutfi
Titel
The treatment of acute liver failure with fractionated plasma separation and adsorption system: Experience in 85 applications
Ist Teil von
Journal of clinical apheresis, 2010, Vol.25 (4), p.195-201
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Introduction: Artificial liver support systems represent a potential useful option for the treatment of liver failure. The outcomes of patients treated with the fractionated plasma separation and adsorption (FPSA) system are presented. Patients and methods: FPSA was performed 85 times for 27 patients (median 3 treatments/patient) with liver failure [85.2% acute liver failure (ALF) and 14.8% acute‐on‐chronic liver failure] using the Prometheus 4008H (Fresenius Medical Care) unit. Citrate was used for anticoagulation. A variety of clinical and biochemical parameters were assessed. Comparisons between pretreatment and post‐treatment data were performed using paired t‐test. Results: The 85 sessions had a mean duration of 6 h. There were significant decreases in total bilirubin (13.18 ± 9.46 mg/dL vs. 9.76 ± 7.05 mg/dL; P < 0.0001), ammonia (167.6 ± 75 mg/dL vs. 120 ± 43.8 mg/dL; P < 0.0001), blood urea nitrogen (BUN; 12.55 ± 13.03 mg/dL vs. 8.18 ± 8.15 mg/dL; P < 0.0001), creatinine (0.54 ± 0.47 mg/dL vs. 0.46 ± 0.37 mg/dL; P = 0.0022) levels, and in pH (7.48 ± 0.05 vs. 7.44 ± 0.08; P = 0.0045). Four patients (14.8%) received liver transplantation after the treatments; in nine patients, transplantation was not necessary anymore (33%); the remaining 14 patients did not receive a transplantation because they were either not appropriate candidates or no organ was available. Overall survival was 48.1% (4 transplanted and 9 treated patients). No hematological complications related to FPSA were observed. Conclusions: FPSA system is a safe and effective detoxification method for patients with liver dysfunction, including ALF. The system is useful as a symptomatic treatment before liver transplantation; in up to 1/3 of the cases, it can even be used as a sole method of treatment. J. Clin. Apheresis 25:195–201, 2010. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0733-2459
eISSN: 1098-1101
DOI: 10.1002/jca.20238
Titel-ID: cdi_proquest_miscellaneous_755179321
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
artificial liver support systems
,
Blood - metabolism
,
Chemical Fractionation
,
Child
,
Citric Acid
,
Female
,
fractionated plasma separation and adsorption
,
Humans
,
liver failure
,
Liver Failure, Acute - metabolism
,
Liver Failure, Acute - mortality
,
Liver Failure, Acute - therapy
,
Liver Transplantation - mortality
,
Male
,
Middle Aged
,
Plasma
,
Renal Dialysis - methods
,
Sorption Detoxification - methods
,
Survival Rate
,
Treatment Outcome
,
Young Adult
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