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Autor(en) / Beteiligte

Titel

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Ist Teil von

Ort / Verlag

New York, NY: Nature Publishing Group

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (PHan combined for ESCC = 7.46 × 10−56, odds ratio (OR) = 1.43; PUygur-Kazakh for ESCC = 5.70 × 10−4, OR = 1.53) and C20orf54 at 20p13 (PHan combined for ESCC = 1.21 × 10−11, OR = 0.86; PUygur-Kazakh for ESCC = 7.88 × 10−3, OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, PHan for GCA = 1.74 × 10−39, OR = 1.55 and C20orf54, PHan for GCA = 3.02 × 10−3, OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

Sprache: Englisch
Identifikatoren: ISSN: 1061-4036
eISSN: 1546-1718
DOI: 10.1038/ng.648
Titel-ID: cdi_proquest_miscellaneous_755133969

Format: –
Schlagworte: Aged, Asian Continental Ancestry Group - genetics, Biological and medical sciences, Carcinoma, Squamous Cell - ethnology, Carcinoma, Squamous Cell - genetics, Care and treatment, Case-Control Studies, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 20, Classical genetics, quantitative genetics, hybrids, Disease susceptibility, Esophageal cancer, Esophageal Neoplasms - ethnology, Esophageal Neoplasms - genetics, Female, Fundamental and applied biological sciences. Psychology, Genetic aspects, Genetic Loci, Genetic Predisposition to Disease, Genetics of eukaryotes. Biological and molecular evolution, Genome-Wide Association Study, Health aspects, Human, Humans, Male, Membrane Proteins - genetics, Membrane Transport Proteins, Middle Aged, Phosphoinositide Phospholipase C - genetics, Polymorphism, Single Nucleotide - physiology, Risk factors, Single nucleotide polymorphisms

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