Neuroreport, 2010-08, Vol.21 (12), p.797-801
2010
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- Autor(en) / Beteiligte
- Titel
- Influence of GABAergic inhibition on concerted activity between the ganglion cells
- Ist Teil von
- Neuroreport, 2010-08, Vol.21 (12), p.797-801
- Ort / Verlag
- Hagerstown, MD: Lippincott Williams & Wilkins
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In this study, the spike discharges of one subtype of bullfrog retinal ganglion cells (dimming detectors) in response to repetitive full field light-OFF stimuli were recorded using multi-electrode arrays. Two different types of concerted activity (precise synchronization and correlated activity) could be distinguished. The nearby cells with overlapped receptive field areas often fired in synchrony, whereas the correlated activity was mainly observed from remote cell pairs with separated receptive fields. After the bicuculline application, the strength of the synchronized activity was increased whereas that of the correlated activity was decreased. These results suggest that the activation of GABAA-receptor-mediated inhibitory pathways differentially modulates the concerted firing of the ganglion cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0959-4965eISSN: 1473-558XDOI: 10.1097/WNR.0b013e32833c5b50Titel-ID: cdi_proquest_miscellaneous_754903884
- Format
- –
- Schlagworte
- Action Potentials - drug effects, Action Potentials - physiology, Animals, Bicuculline - pharmacology, Biological and medical sciences, Cell Communication - drug effects, Cell Communication - physiology, Eye and associated structures. Visual pathways and centers. Vision, Fundamental and applied biological sciences. Psychology, GABA Antagonists - pharmacology, gamma-Aminobutyric Acid - physiology, Neural Inhibition - drug effects, Neural Inhibition - physiology, Neural Pathways - cytology, Neural Pathways - drug effects, Neural Pathways - metabolism, Organ Culture Techniques, Photic Stimulation - methods, Rana catesbeiana, Receptors, GABA-A - drug effects, Receptors, GABA-A - metabolism, Receptors, GABA-A - physiology, Retinal Ganglion Cells - cytology, Retinal Ganglion Cells - drug effects, Retinal Ganglion Cells - physiology, Vertebrates: nervous system and sense organs, Vision, Ocular - physiology, Visual Fields - physiology